GeneAb™

CD1a

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$130.00

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Cat. No.

IHC530-100

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Description

CD1a is part of a heterodimer with β-2-microglobulin which mediates the capture and presentation of antigens, primarily lipid and glycolipid antigens of self or microbial origin, to T cells. CD1a is expressed on interdigitating and dermal dendritic cells, veiled cells, Langerhans cells, antigen-presenting cells of the lymph nodes, and cortical thymocytes. Anti-CD1a stains Langerhans cell histiocytosis and cortical T LBL/L pre-T lymphoblastic lymphoma and leukemia. In concert with S100 and CD68, CD1a is very useful for differentiating Rosai-Dorfman disease from other histiocytic diseases.

Specifications

Clone IHC530
Source Mouse Monoclonal
Positive Control Skin, Thymus
Dilution Range 1:100 - 1:200

References

  1. Melián A, et al. Curr Opin Immunol. 1996; 8:82–8.
  2. Park SH, et al. Nature. 2000; 406:788–92.
  3. Angel CE, et al. Blood. 2009: 113:1257-67.
  4. Krenacs L, et al. J Pathol. 1993; 171:99-104
  5. Emile JF, et al. Am J Surg Pathol. 1995; 19:636-41.
  6. Dalia S, et al. Cancer Control. 2014; 21:322-7.