GeneAb™

CD34

(In the pipeline)

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$130.00

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Cat. No.

IHC034-100

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Description

Cluster of differentiation 34 (CD34) is a transmembrane glycoprotein expressed on hematopoietic stem and progenitor cells, vascular endothelium, embryonic fibroblasts, and rare glial cells in nervous tissue. CD34 is the most used marker for characterizing blasts in leukemia. CD34 is also present in some soft tissue tumors including solitary fibrous tumors and gastrointestinal stromal tumors. Proliferating endothelial cells seem to upregulate CD34 expression. Although specificity is low, Anti-CD34 reacts positively with more than 85% of angiosarcoma and Kaposi’s sarcoma.

Specifications

Clone IHC034
Source Mouse Monoclonal
Positive Control Tonsil, Placenta
Dilution Range 1:100 - 1:200

References

  1. Nielsen JS, et al. J Cell Sci. 2008; 121:3683–92.
  2. Kong Y, et al. Leukemia. 2008; 22:1207-13.
  3. Kisluk J, et al. Adv Clin Exp Med. 2013; 22:33-39.
  4. Ramani P, et al. Histopathology. 1990; 17:237-242.
  5. Sankey EA, et al. J Pathol. 1990; 161:267-71.
  6. Mikalsen LT, et al. Anticancer Res. 2011; 31:4053-60.