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GeneAb<sup>TM</sup> CD44 [IHC044] on Breast Cancer

GeneAb^TM CD44 [IHC044] on Breast Cancer

GeneAb<sup>TM</sup> CD44 [IHC044] on Breast Cancer

Designations

IVD: RUO:

Reference Panels

Breast/Gynecological Pathology

Dermatopathology

Gastrointestinal (GI) Pathology

Genitourinary (GU) Pathology

Head and Neck Pathology

Hematopathology

Neuropathology

Pediatric Pathology

Pulmonary Pathology

Soft Tissue Pathology

Cytopathology

GeneAb™

CD44

Select Format:

Concentrate

Predilute

Positive Control Slides

Select Volume:

0.1 ml	1 ml
7 ml	25 ml
3 slides/package

Price:

$45.00

Quantity:

Cat. No.

IHC044-100

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Description

Cluster of differentiation 44 (CD44) is a glycoprotein receptor for hyaluronic acid, which plays a fundamental role in cellular adhesion, stromal binding, migration, and cell-cell interactions. Studies have suggested that the CD44-hyaluronate interaction is central to tumor invasiveness. Positive staining with Anti-CD44 is implicated in a multitude of different cancer types, including breast, prostatic, renal cell, colonic, hepatocellular, and genitourinary carcinomas, as well as Non-Hodgkin’s Lymphoma, metastatic melanoma, gastric cancer, and some soft tissue tumors. It has also been demonstrated that there is a positive correlation between tumor progression and increased expression of CD44v, a high molecular weight CD44 isoform that has been described in epithelial cells. Given the expression of CD44 in a wide range of cancers, the most practical application of CD44 immunostaining is its use in discriminating between urothelial transitional cell carcinoma in situ from non-neoplastic changes in the urothelium.

References
1. Li F, et al. Cell Res. 2007; 17:3-14.
2. Ponta H, et al. Nat Rev Mol Cell Biol. 2003; 4:33-45.

Specifications

Clone IHC044

Source Mouse Monoclonal

Positive Control Benign Urothelium

Dilution Range 1:100 - 1:400

Literature

catalog — Catalog

Data Sheet

SDS Sheet

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