GeneAb™

CD5

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$165.00

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Cat. No.

IHC538-100

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Description

Cluster of differentiation 5 (CD5) is expressed in high levels on the surface of T cells, while controversy surrounds the expression levels and role of CD5 in B cells. As a part of a diagnostic panel, its utility lies predominantly as a marker for T cells, with over 70% of T cell neoplasms expressing CD5. In particular, it is correlated with chronic lymphocytic leukemia/small lymphocytic lymphomas, mantle cell lymphoma, as well as a subset of diffuse large B cell lymphomas. CD5 demonstrates positive expression in thymic carcinomas, and is not as sensitive as CD3. CD5 also has value as a prognostic indicator, being associated with poor prognosis in acute T cell lymphoblastic leukemia.

Specifications

Clone IHC538
Source Mouse Monoclonal
Positive Control Tonsil, Lymph Node
Dilution Range 1:100 - 1:200

References

  1. Tan S, et al. Br J Dermatol. 2003; 149:542-553.
  2. Chang C, et al. Mod Pathol. 2002; 15:1051-1057.