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Cluster of differentiation 99 (CD99) is a glycosylated transmembrane protein expressed by lymphocytes, cortical thymocytes, granulosa cells of the ovary, pancreatic islet cells, Sertoli cells, and endothelial cells. CD99 produces diffuse membrane staining patterns on nearly all Ewing's sarcoma and primitive peripheral neuroectodermal tumors. CD99 may be found in synovial sarcoma, neuroendocrine carcinoma, acute myeloid leukemia, mesenchymal chondrosarcoma, lymphoblastic lymphoma, small round blue cell tumors, solitary fibrous tumors, vascular tumors, and myeloid sarcoma and produce heterogeneous staining patterns, which must be accompanied by other antibody staining for a final diagnosis.
  • References
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    2. Fellinger EJ, et al. Amer J Surg Pathol. 1992; 16:746-55.
    3. Dworzak MN, et al. Blood. 1994; 83:415–25.
    4. Choi EY, et al. J Immunol. 1950; 161:749–54.
    5. Bernard G, et al. Eur J Immunol. 2000; 30:3061–5.
    6. Oh KI, et al. Exp Mol Med. 2007; 39:176–84.
    7. Ambros IM, et al. Cancer. 1991; 67:1886-93.


Clone IHC099
Source Mouse Monoclonal
Positive Control Ewings Sarcoma, Pancreas
Dilution Range 1:50-1:200