GeneAb™

COX-2

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Cat. No.

IHC550-100

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Description

COX-2, also known as cyclooxygenase 2, catalyzes the conversion of arachidonic acid to prostaglandin H2. The inhibition of COX-2 using non-steroidal anti-inflammatory agents limits angiogenesis and tumor growth, and increases apoptosis. The overexpression of COX-2 is linked to increased microvascular density.
  • References
    1. Stoehlmacker J, et al. Semin Oncol. 2003; 30:10-6.
    2. Gallo O, et al. Hum Pathol. 2002; 33:708-14.
    3. Sano H, et al. Cancer Res. 1995; 55:3785-9.
    4. Denkert C, et al. Cancer. 2003; 97:2978-87.
    5. Sheehan KM, et al. Hum Pathol. 2003; 34:1242-6.

Specifications

Clone IHC550
Source Mouse Monoclonal
Positive Control Colon Adenocarcinoma
Dilution Range 1:50-1:200

Literature