GeneAb™

Carbonic Anhydrase IX (CA IX)

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$145.00

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Cat. No.

IHC524-100

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Description

Carbonic Anhydrase IX (CA IX) is a transmembrane protein involved in catalyzing the reversible hydration of carbon dioxide. CA IX is a useful marker for epithelial malignancies of the uterus, cervix, lung, breast, and kidney (including clear cell renal cell carcinoma or RCC). Urothelial carcinomas produce diffuse-to-multifocal staining, while Collecting Duct Carcinoma (CDC) yields extremely weak and focal staining.

Specifications

Clone IHC524
Source Mouse Monoclonal
Positive Control Clear Cell Renal Cell Carcinoma
Dilution Range 1:100 - 1:200

References

  1. Tostain J, et al. Eur J Cancer. 2010; 46:3141-3148.
  2. Kivela AJ, et al. Histochem Cell Biol. 2000; 114:197–204.
  3. Al-Ahmadie HA, et al. Am J Surg Pathol. 2008; 32:377–382.
  4. Ivanov S, et al. Am J Pathol. 2001; 158:905–919.
  5. Leppilampi M, et al. World J Gastroenterol. 2003; 9:1398–1403.
  6. Dorai T, et al. Cancer Invest. 2006; 24:754–779.