Collagen Type IV

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Collagen Type IV is a primary component in the basal lamina that is used as a marker to observe the presence of the lamina and examine its structure. In addition to the epithelial basal lamina, Anti-Collagen Type IV stains mesenchymal components. It is useful for identifying soft tissue cancers including schwannomas and leiomyomas. Anti-Collagen Type IV frequently reacts with these tissues after becoming well-differentiated and malignant. The use of Anti-Collagen Type IV produces more reliable results than non-specific silver reticulum stains when investigating the vascular elements of neoplasms, hemangiopericytoma, angiosarcoma and epithelioid hemangioendothelioma.
  • References
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    3. Sakr WA, et al. Hum Pathol. 1987; 18:1043-50.
    4. Barsky SH, et al. Am J Surg Pathol. 1983; 7:667-77.
    5. De Iorio P, et al. Anticancer Res. 2001; 21:1395-9.
    6. Maatta M, et al. J Histochem Cytochem. 2001; 49:711-26.
    7. Schmehl K, et al. Int J Colorectal Dis. 2000; 15:39-48.
    8. Felix A, et al. Hum Pathol. 1999; 30:964-9.
    9. Damiani S, et al. Virchows Arch. 1999; 434:227-34.


Clone IHC549
Source Mouse Monoclonal
Positive Control Lung, Muscle
Dilution Range 1:100 - 1:400