GeneAb™

Cyclin E1

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$130.00

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Cat. No.

IHC553-100

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Description

Cyclin E1 is a key cell cycle regulator in normal cells. Many studies have found Cyclin E1 to be linked to disease progression and patient prognoses in several cancers including breast, bladder, colon, and ovarian carcinomas. Cyclin E1 is commonly uncontrolled in various cancers, and current research has found Cyclin E1 overexpression to be the cause for resistance against trastuzumab in HER2(+) breast cancer patients.

Specifications

Clone IHC553
Source Mouse Monoclonal
Positive Control Breast Carcinoma, Placenta
Dilution Range 1:100 - 1:200

References

  1. Okuda M, et al. Cell. 2000; 103:127-40.
  2. Chen Z, et al. Dev Cell. 2002; 3:339-50.
  3. Huang H, et al. Science. 2006; 314:294-7.
  4. Scaltriti, M, et al. Proc Natl Acad Sci U S A. 2011; 108:3761-6.