GeneAb™

PAX-5

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$125.00

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Cat. No.

IHC005-100

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Description

PAX-5 is a member of the paired box (PAX) family of transcription factors, which are key regulators in early development. The PAX-5 gene encodes the B-cell lineage specific activator protein (BSAP), whose expression is limited to early stages of B-cell differentiation. Anti-PAX-5 is useful in differentiating between classic Hodgkin’s lymphoma versus multiple myeloma and solitary plasmacytoma, as the protein is expressed in mature and precursor B-cell non-Hodgkin’s lymphomas/leukemias while being absent from the other two conditions. Diffuse large B-cell lymphomas are positive for PAX-5, with the exception of those with terminal B-cell differentiation, and T-cell neoplasms do not stain with Anti-PAX-5.

Specifications

Clone IHC005
Source Mouse Monoclonal
Positive Control Tonsil
Dilution Range 1:100 - 1:200

References

  1. Torlakovic E, et al. Am J Surg Pathol. 2002; 26:1343-50.
  2. Willenbrock K, et al. Lab Invest. 2002; 82:1103-9.
  3. Falini B, et al. Blood. 2002; 99:409-26.
  4. Schwering I, et al. Blood. 2003; 101:1505-12.