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Somatostatin is a peptide hormone that acts in the regulation of endocrine function, neurotransmission, and cell proliferation. It is secreted from cells of the hypothalamus, stomach, intestine, and pancreas, and can also be found in bronchopulmonary endocrine cells, thymic endocrine cells, and thyroid C-cells. Somatostatin is a useful marker for D-cell of pancreatic islets, which are used in the identification of islet cell hyperplasia and associated somatostatinomas. Anti-Somatostatin is also used to detect somatostatin-containing cells in pancreatic tumors and islet cells originating in pancreatic ductules.
  • References
    1. Krejs GJ. Scand J Gastroenterol Suppl. 1986; 119:47-53.
    2. Tzaneva MA. Acta Histochem. 2003; 105:191-201.
    3. Krejs GJ, et al. N Eng J Med. 1982; 306:580-90.
    4. Friesen SR. N Eng J Med. 1982; 306:580-90.
    5. Kanavaros P, et al. Histol Histopathol. 1990; 5:325-8.
    6. Chejfec G, et al. Ultrastruct Pathol. 1992; 16:537-45.
    7. Somers G, et al. Gastroenterology. 1983; 85:1192-8.
    8. Erlandsen SL. Williams and Wilkins, Baltimore. 1980; 140-55.


Clone IHC664
Source Mouse Monoclonal
Positive Control Pancreas
Dilution Range 1:50-1:200