GeneAb™

Spectrin

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$150.00

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Cat. No.

IHC666-100

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Description

Spectrin is a protein that acts in actin cross-linking and forming scaffolds of the cytoskeleton, thereby aiding in the determination of cell shape, organization of organelles, and arrangement of transmembrane proteins. It is expressed in many cell types found in muscles, red blood cells, and red cell precursors. Mutations in the spectrin gene result in a number of hereditary red blood cell disorders such as pyropoikilocytosis, spherocytic hemolytic anemia, and elliptocytosis type 2. Anti-Spectrin is also useful in the diagnosis of erythroid leukemias and other non-hereditary erythroid disorders.

Specifications

Clone IHC666
Source Mouse Monoclonal
Positive Control Bone Marrow
Dilution Range 1:100 - 1:200

References

  1. Gorman EB, et al. Mod Pathol. 2007; 20:1245–1252.
  2. Sadahira Y, et al. J Clin Pathol. 1999; 52: 919-21.
  3. Nehls V, et al. Am J Pathol. 1993; 142:1565-73.
  4. Muller M, et al. J Vet Med A Physiol Pathol Clin Med. 2001; 48:51-7.
  5. Terada N, et al. J Anat. 1997; 190:397-404.