GeneAb™

Tryptase

(In the pipeline)

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$145.00

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Cat. No.

IHC678-100

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Description

Mast cell tryptase, also known simply as tryptase, is a highly abundant proteinase stored in basophils and the secretory granules of mast cells, which is released upon cellular activation. The enzyme is therefore considered a key marker for mast cell activation, as well as acting as a critical mediator of inflammation. Elevated levels of serum tryptase occur in both anaphylactic and anaphylactoid reactions. Anti-Tryptase acts as a good marker for mast cells, basophils, and their derivatives.

Specifications

Clone IHC678
Source Mouse Monoclonal
Positive Control Tonsil
Dilution Range 1:100 - 1:200

References

  1. Li CY. Leuk Res. 2001; 25:537-41.
  2. Aoki, et al. Int Arch Allergy Immunol. 2003; 130:216-23.
  3. Ghott, et al. Am J Surg Pathol. 2003; 27:1013-9.
  4. Jordan JH, et al. Hum Pathol. 2001; 32:545-52.
  5. Gordon LK, et al. Clin Immunol. 2000; 94:42-50.
  6. Roberts IS, et al. J Clin Pathol. 2000; 53:858-62.
  7. Fiorucci L, et al. Cell Mol Life Sci. 2004; 61:1278-1295.