GeneAb™

p53

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Cat. No.

IHC053-100

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Description

p53, also known as tumor protein 53 or TP53, is a tumor suppressor and transcription factor that functions in a number of anti-cancer activities including DNA repair, cell-cycle arrest, and apoptosis in response to DNA damage or other stressors. Mutations in p53 are linked to a number of malignant tumors, including those of the breast, ovarian, bladder, colon, lung, and melanoma. Anti-p53 staining has been used to detect intratubular germ cell neoplasia, and also to distinguish between uterine serous carcinoma and endometrioid carcinoma.
  • References
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    5. Sheehan KM, et al. Hum Pathol. 2003; 34:1242-1246.
    6. Moore BE, et al. Appl Immunohistochem Mol Morphol. 2001; 9:203-6.
    7. Mauri FA, et al. Int J Oncol. 1999; 15:1137-47.
    8. Caffo O, et al. Clin Cancer Res. 1996; 2:1591-9.
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    11. Zen ZS, et al. J Clin Oncol. 1994; 12:2043-50.
    12. Quinlan DC, et al. Cancer Res. 1992; 53:4828-31.
    13. Alexiev BA, et al. Gen Diagn Pathol. 1997; 142:271-9.

Specifications

Clone IHC053
Source Mouse Monoclonal
Positive Control Colon Carcinoma
Dilution Range 1:50-1:200

Literature