Epithelial Cell Adhesion Molecule (EpCAM) is a transmembrane glycoprotein that mediates cell–cell adhesion in epithelia. It is normally present on most baso-lateral surfaces of normal epithelial cells and is absent in myoepithelial cells, hepatocytes, adult squamous epithelia, mesothelial cells, and fibroblasts. Anti-EpCAM stains most adenocarcinomas and neuroendocrine tumors, including small cell carcinomas. A minority of renal clear cell carcinoma, renal oncocytoma, and hepatocellular carcinoma stain positively for EpCAM, while Anti-EpCAM stains nearly all basal cell carcinoma. Anti-EpCAM stains chromophobe renal cell carcinoma, papillary renal cell carcinoma, and cholangiocarcinoma more frequently. Anti-EpCAM can be useful for distinguishing malignancy in the peritoneal and pleural cavities.


  • Available Formats:

    0.1 ml Concentrate - IHC567-100

    1.0 ml Concentrate - IHC567-1

    7.0 ml Pre-Dilute - IHC567-7




    Source Mouse Monoclonal
    Positive Control Colon Adenocarcinoma
    Dilution Range 1:50-1:200


    1. Vranic S, et al. Mod Pathol. 2010; 23:644-53.
    2. Cascio MJ, et al. Mod Pathol. 2010; 23:574.
    3. Tawbi H, et al. Oncologist. 2008; 13:459.
    4. Ch’ng S, et al. Hum Pathol. 2008; 39:344-9.
    5. Van Damme, et al. BMC Cancer. 2010; 10:189.

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