Description

Isocitrate Dehydrogenase 1 (IDH1) is a soluble, cytosolic enzyme involved in the TCA metabolic cycle. The most notable mutation in this enzyme, R132H, is clinically indicated in the majority of astrocytomas and oligodendroglial tumours, with the mutation being associated with more favourable prognosis and increased survival in those patients. IDH1 R132H is also useful in the differential diagnosis between anaplastic glioma and glioblastoma.

IDH1 R132H

SKU: IHC132
  • Available Formats:

    0.1 ml Concentrate - IHC132-100

    1.0 ml Concentrate - IHC132-1

    7.0 ml Pre-Dilute - IHC132-7

     

    Clone

    IHC132

    Source Mouse Monoclonal
    Positive Control Astrocytoma
    Dilution Range 1:50-1:200

     

    1. Cui D, et al. Int J Biochem Cell Biol. 2016;71:72-81.
    2. Balss J, et al. Acta Neuropathol. 2008; 116:597-602.
    3. Capper D, et al. Brain Pathol. 2010; 20:245-54.
    4. Camelo-Piragua S, et al. Acta Neuropathol. 2010; 119:509-11.

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