Multidrug Resistance 3 (MDR3), also known as ATP Binding Cassette Subfamily B Member 4 (ABCB4), is a membrane-associated protein belonging to the superfamily of ATP-binding cassette transporters. MDR3 is an energy-dependent phospholipid efflux translocator that mediates the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte, and also acts as a positive regulator of biliary lipid secretion. Defects in MDR3 are associated with progressive familial intrahepatic cholestasis type 3 and gallbladder disease type 1. Co-overexpression of MDR3 and MRP1 has been documented as correlating with blastemal subtype and high-risk prognosis of Wilms’ tumor patients.


  • Available Formats:

    0.1 ml Concentrate - IHC621-100

    1.0 ml Concentrate - IHC621-1

    7.0 ml Pre-Dilute - IHC621-7




    Source Mouse Monoclonal
    Positive Control
    Adrenal Cortex
    Dilution Range 1:50-1:200


    1. Hontecillas-Prieto L, et al. Oncotarget. 2017; 8:11173-86.
    2. van Helvoort A, et al. Cell. 1996; 87:507-17.
    3. Morita SY, et al. Hepatology. 2007; 46:188-99.
    4. Crawford AR, et al. J Clin Invest. 1997; 100:2562-7.
    5. de Vree JML, et al. Proc Natl Acad Sci U S A. 1998; 95.
    6. Rosmorduc O, et al. Gastroenterology. 2001; 120:1459-67.

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