The p16 (p16INK4A) protein is a cyclin-dependent kinase inhibitor that plays an important regulatory role in the cell cycle. By controlling the transition between the G1 and S phases through regulation of retinoblastoma protein, p16 decelerates cellular differentiation and therefore acts as a tumor suppressor, making it the key marker in several human cancers including head and neck cancer, perianal lesions, melanomas, gliomas, lymphomas, and some types of leukemia. p16 is also clinically indicated in carcinomas of the esophagus, pancreas, lung, biliary tract, liver, colon, and urinary bladder.


  • Available Formats:

    0.1 ml Concentrate

    1.0 ml Concentrate

    7.0 ml Pre-Dilute




    Source Mouse Monoclonal
    Positive Control Cervical Cancer, Normal Pancreas, Normal Tonsil
    Dilution Range 1:50-1:200


    1. Sano T, et al. Am J Pathol. 1998; 153:1741-8.
    2. Agoff SN, et al. Mod Pathol. 2003; 16:665-73.
    3. Negri G, et al. Am J Surg Pathol. 2003; 27:187-93.
    4. Klaes R, et al. Int J Cancer. 2001; 92:276-84.
    5. Klaes R, et al. Am J Surg Pathol. 2002; 26:1389-99.
    6. Negri G, et al. Virchows Arch. 2004; 445:616-20.

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