p63 is a tumor suppressor protein that is very similar to p53 in structure and function, while being homologous to p73. p63 is important in development and differentiation, and has been identified as a useful marker for distinguishing between lung squamous cell carcinomas and adenocarcinomas. Anti-p63 is also used to differentiate between benign and malignant prostate and breast lesions, due to its labeling of the nuclei of myoepithelial cells in both tissue types.
0.1 ml Concentrate
1.0 ml Concentrate
7.0 ml Pre-Dilute
Source Mouse Monoclonal Positive Control Skin, Squamous Cell Carcinoma, Prostate Dilution Range 1:50-1:200
- Yang A, et al. Mol Cell. 1998; 2:305-16.
- Signoretti S, et al. Am J Pathol. 2000; 157:1769-75.
- Yang A, et al. Nature. 1999; 398:714-8.
- Barbareschi M, et al. Am J Surg Pathol. 2001; 25:1054-60.
- Werling RW, et al. Am J Surg Pathol. 2003; 27:82-90.
- Rajal B Shah, et al. Am J Surg Pathol. 2002; 26:1161-8.
- Iacono ML, et al. J Thorac Oncol. 2011; 6:473-81.
- Mukhopadhyay S, et al. Am J Surg Pathol. 2011; 35:15-25.
- Conde E, et al. PLoS One. 2010; 5:e12209.
- Uke M, et al. Cytopathology. 2010; 21:56-63.