Description

PAX-5 is a member of the paired box (PAX) family of transcription factors, which are key regulators in early development. The PAX-5 gene encodes the B-cell lineage specific activator protein (BSAP), whose expression is limited to early stages of B-cell differentiation. Anti-PAX-5 is useful in differentiating between classic Hodgkin’s lymphoma versus multiple myeloma and solitary plasmacytoma, as the protein is expressed in mature and precursor B-cell non-Hodgkin’s lymphomas/leukemias while being absent from the other two conditions. Diffuse large B-cell lymphomas are positive for PAX-5, with the exception of those with terminal B-cell differentiation, and T-cell neoplasms do not stain with Anti-PAX-5.

PAX-5

SKU: IHC005
  • Available Formats:

    0.1 ml Concentrate - IHC005-100

    1.0 ml Concentrate - IHC005-1

    7.0 ml Pre-Dilute - IHC005-7

     

    Clone

    IHC005

    Source Mouse Monoclonal
    Positive Control Tonsil
    Dilution Range 1:50-1:200

     

    1. Torlakovic E, et al. Am J Surg Pathol. 2002; 26:1343-50.
    2. Willenbrock K, et al. Lab Invest. 2002; 82:1103-9.
    3. Falini B, et al. Blood. 2002; 99:409-26.
    4. Schwering I, et al. Blood. 2003; 101:1505-12.

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