Description

PAX-8 is a member of the paired box (PAX) family of transcription factors, which are key regulators in early development. This protein plays a role in development of thyroid follicular cells and the expression of thyroid-specific genes, with mutations in the PAX-8 gene linked to thyroid follicular carcinomas, atypical thyroid adenomas, and thyroid dysgenesis. The PAX-8 protein is expressed in simple ovarian inclusion cysts and non-ciliated mucosal cells of the fallopian tubes, but is absent from normal ovarian surface epithelial cells. PAX-8 is also not expressed in normal lung or lung carcinomas. Reports have associated PAX-8 expression with renal carcinoma, nephroblastoma, and seminoma, and have indicated PAX-8 as a useful marker for renal epithelial tumors, ovarian cancer, and for differential diagnoses in lung and neck tumors. Anti-PAX-8 can be useful in determining the primary site of invasive micropapillary carcinomas of ovary from bladder, lung, and breast, when used in adjunct with a panel of organ-specific markers such as uroplakin, mammaglobin, and TTF-1.

PAX8

SKU: IHC008
  • Available Formats:

    0.1 ml Concentrate - IHC008-100

    1.0 ml Concentrate - IHC008-1

    7.0 ml Pre-Dilute - IHC008-7

     

    Clone

    IHC008

    Source Mouse Monoclonal
    Positive Control Ovarian Carcinoma (Non-Mucinous Carcinoma), Thyroid Carcinoma, Renal Cell Carcinoma
    Dilution Range 1:50-1:200

     

    1. Tong GX, et al. Mod Pathol. 2009; 22:1218-27.
    2. Nonaka D, et al. Mod Pathol. 2008; 21:192-200.
    3. Tamara L, et al. Am J Surg Pathol. 2009; 33:1037-41.
    4. Nikiforova MN, et al. Am J Surg Pathol. 2002; 26:1016-23.
    5. Nonaka D, et al. Am J Surg Pathol. 2008; 32:1566-71.
    6. Marques AR, et al. J Clin Endocrinol Metab. 2002; 87:3947-52.
    7. Tina DP, et al. J Biol Chem. 2003; 278:3395-3402.
    8. Bowen NJ, et al. Gynecol Oncol. 2007; 104:331-7.
    9. Zhang P, et al. Pathol Int. 2006; 56:240-245.

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