Description

Programmed Death 1 (PD-1) is a member of the CD28/CTLA-4 family of T-cell regulators, expressed as a co-receptor on the surface of activated T-cells, B-cells, and macrophages. New studies have suggested that the PD-1/PD-L1 signaling pathway may be linked to anti-tumor immunity, as PD-L1 has been shown to induce apoptosis of activated T cells or inhibit activity of cytotoxic T cells. In comparison to CD10 and Bcl-6, PD-1 is expressed by fewer B cells and has therefore been considered a more specific and useful diagnostic marker for angioimmunoblastic T-cell lymphoma. Therapies targeted toward the PD-1 receptor have shown remarkable clinical responses in patients with various types of cancer, including non–small-cell lung cancer, melanoma, and renal-cell cancer.

  •  

PD-1

SKU: IHC001
  • Available Formats:

    0.1 ml Concentrate - IHC001-100

    1.0 ml Concentrate - IHC001-1

    7.0 ml Pre-Dilute - IHC001-7

     

    Clone

    IHC001

    Source Mouse Monoclonal
    Positive Control Tonsil, Lymph Node
    Dilution Range 1:50-1:200

     

    1. Dorfman DM, et al. Am J Surg Pathol. 2006; 30:802-10.
    2. Hamanishi J, et al. Proc Natl Acad Sci USA. 2007; 104:3360-5.
    3. Kobayashi M, et al. J Rheumatol. 2005; 32:2156-63.
    4. Konishi J, et al. Clin Cancer Res. 2004; 10:5094-100.
    5. Mataki N, et al. Am J Gastroenterol. 2007; 102:302-12.
    6. Kim JW, et al. Oncology (Williston Park). 2014; 28:15-28.
    7. Tumeh PC, et al. Nature. 2014; 515:568-71.
    8. D’Incecco A, et al. Br J Cancer. 2015; 112:95-102.
    9. Tykodi SS. Onco Targets Ther. 2014; 7:1349-59.

Follow Us

  • Facebook - White Circle
  • Twitter - White Circle
  • Instagram - White Circle

Subscribe to receive our latest promotions and updates

Contact Us

#1 - 3691 Viking Way

Richmond, BC V6V 2J6

[email protected]

[email protected]

[email protected]

(604) 244-9962

Copyright © 2019 GenomeMe