Description

Programmed Death-Ligand 1 (PD-L1), also known as CD274 or B7 Homolog 1 (B7-H1), is a transmembrane protein involved in suppressing the immune system and rendering tumor cells resistant to CD8+ T cell-mediated lysis through binding of the Programmed Death-1 (PD-1) receptor. Overexpression of PD-L1 may allow cancer cells to evade the actions of the host immune system. In renal cell carcinoma, upregulation of PD-L1 has been linked to increased tumor aggressiveness and risk of death, and, in ovarian cancer, higher expression of this protein has lead to significantly poorer prognosis. PD-L1 has also been linked to systemic lupus erythematosus and cutaneous melanoma. When considered in adjunct with CD8+ tumor-infiltrating lymphocyte density, expression levels of PD-L1 may be a useful predictor of multiple cancer types, including stage III non-small cell lung cancer, hormone receptor negative breast cancer, and sentinel lymph node melanoma.

PD-L1

SKU: IHC411
  • Available Formats:

    0.1 ml Concentrate

    1.0 ml Concentrate

    7.0 ml Pre-Dilute

     

    Clone

    IHC411

    Source Mouse Monoclonal
    Positive Control Tonsil, Lung Adenocarcinoma
    Dilution Range 1:50-1:200

     

    1. Ostrand-Rosenberg S, et al. J Immunol. 2014; 193:3835-41.
    2. Tokito T, et al. Eur J Cancer. 2016; 55:7-14.
    3. Park IH, et al. Clin Breast Cancer. 2016; 16:51-8.
    4. Kakavand H, et al. Mod Pathol. 2015; 28: 1535-44.
    5. Xia B, et al. Immunotherapy. 2016; 8:279-98.
    6. Patel SP, et al. Mol Cancer Ther. 2015; 14:847-56.
    7. Singh BP, et al. Cancers (Basel). 2016; 8.
    8. Chemnitz JM, et al. J Immunol. 2004; 173:945–54.
    9. Thompson RH, et al. Proc Natl Acad Sci USA. 2004; 101:17174–9.
    10. Hamanishi J, et al. Proc Natl Acad Sci USA. 2007; 104:3360–5.
    11. Mozaffarian N, et al. Rheumatology, 2008; 47:1335–41.

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