Description

Postmeiotic Segregation Increased 2 (PMS2) is a DNA repair protein involved in mismatch repair. Mutations and deficiencies in the PMS2 gene have been linked to microsatellite instability, and malignancies such as hereditary nonpolyposis colorectal cancer and endometrial cancer. Expression levels of the PMS2 protein may be useful as a screening tool for Lynch syndrome after a colorectal cancer diagnosis. Anti-PMS2 is recommended to be used as part of a panel along with antibodies against MLH1, MSH2, and MSH6.

PMS2

SKU: IHC412
  • Available Formats:

    0.1 ml Concentrate - IHC412-100

    1.0 ml Concentrate - IHC412-1

    7.0 ml Pre-Dilute - IHC412-7

     

    Clone

    IHC412

    Source Mouse Monoclonal
    Positive Control Colon
    Dilution Range 1:50-1:200

     

    1. Cohn DE, et al. Int J Gynecol Cancer. 2008; 18:136-40.
    2. Modica I, et al. Am J Surg Pathol. 2007; 31:744-51.
    3. Sordet C, et al. Joint Bone Spine. 2006; 73:646-54.
    4. Balogh GA, et al. Int J Mol Med. 2006; 18:853-7.
    5. Halvarsson B, et al. Fam Cancer. 2006; 5:353-8.
    6. Gologan A, et al. Clin Lab Med. 2005; 25:179-96.
    7. Lagerstedt Robinson K, et al. J Natl Cancer Inst. 2007; 99:291-9.
    8. Hendriks YM, et al. Gastroenterology. 2006; 130:312-22.
    9. Truninger K, et al. Gastroenterology. 2005; 128:1160-71.
    10. Hampel H, et al. N Engl J Med. 2005; 352:1851-60.
    11. Warusavitarne J, et al. Int J Colorectal Dis. 2007; 22:739-48.
    12. Gill S, et al. Clin Cancer Res. 2005; 11:6466-71.
    13. Modica I, et al. Am J Surg Pathol. 2007; 31:744-51.
    14. Shia J, et al. Am J Surg Pathol. 2009; 33:1639-45.
    15. Kets CM, et al. Mod Pathol. 2006; 19:1624-30.
    16. Thompson RH, et al. Proc Natl Acad Sci USA. 2004; 101:17174–9.
    17. Hamanishi J, et al. Proc Natl Acad Sci USA. 2007; 104:3360–5.
    18. Mozaffarian N, et al. Rheumatology, 2008; 47:1335–41.

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