Description

SRY (Sex Determining Region Y)-Box 10 (SOX-10), also known as transcription factor SOX-10, is a nuclear transcription factor that acts in regulation of embryonic development and in the specification and differentiation of cells of melanocytic lineage. SOX-10 is diffusely expressed in neurofibromas and schwannomas, and mutations in the SOX-10 gene are linked to Waardenburg-Shah and Waardenburg-Hirschsprung disease. Anti-SOX-10 has been shown to be sensitive for conventional, spindled, and desmoplastic melanoma, and has been used to detect metastatic melanoma and nodal capsular nevus in sentinel lymph nodes.

SOX-10

SKU: IHC010
  • Available Formats:

    0.1 ml Concentrate - IHC010-100

    1.0 ml Concentrate - IHC010-1

    7.0 ml Pre-Dilute - IHC010-7

     

    Clone

    IHC010

    Source Mouse Monoclonal
    Positive Control Melanoma, Skin Melanocytes
    Dilution Range 1:50-1:200

     

    1. Pingault V, et al. Nat Genet. 1998; 18:171-3.
    2. Bondurand N, et al. Hum Mol Genet. 2000; 8:1785-9.
    3. Kelsch RN. BioEssays. 2006; 28:788.
    4. Nonaka D, et al. Am J Surg Pathol. 2008; 32:1291-8.
    5. Chorny JA, et al. Am J Dermatopathol. 2002; 24:309-12.
    6. Robson A, et al. Histopathology. 2001; 38:135-40.
    7. Longacre T, et al. Am J Surg Pathol. 1996; 20:1489-500.
    8. Ramos-Herberth FI, et al. J Cutan Pathol. 2010; 37:944–52.

Follow Us

  • Facebook - White Circle
  • Twitter - White Circle
  • Instagram - White Circle

Subscribe to receive our latest promotions and updates

Contact Us

#1 - 3691 Viking Way

Richmond, BC V6V 2J6

[email protected]

[email protected]

[email protected]

(604) 244-9962

Copyright © 2019 GenomeMe