Description

Transcription Factor E3 (TFE3) is a transcription factor that binds to the MUE3-type E-box sequences involved in TGF-β signalling. Anti-TFE3 staining is the most sensitive and specific indicator of Xp11 translocation renal cell carcinomas. Since alveolar soft part sarcoma (ASPS) is characterized by a specific chromosomal rearrangement resulting in a chimeric transcription factor (ASPSCR1-TFE3), this TFE3 IVD antibody is also a useful diagnostic tool for recognizing ASPS.

TFE3

SKU: IHC672
  • Available Formats:

    0.1 ml Concentrate - IHC672-100

    1.0 ml Concentrate - IHC672-1

    7.0 ml Pre-Dilute - IHC672-7

     

    Clone

    IHC672

    Source Mouse Monoclonal
    Positive Control Testes, Melanoma, Xp11.2 Translocation Renal Cell Carcinoma
    Dilution Range 1:50-1:200

     

    1. Argani P, et al. Am J Clin Pathol. 2006; 126:332-4.
    2. Argani P, et al. Am J Surg Pathol. 2003; 27:750-61.
    3. Lazar AJ, et al. Histopathology. 2009; 55:750-5.

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