Transcription Factor E3 (TFE3) is a transcription factor that binds to the MUE3-type E-box sequences involved in TGF-β signalling. Anti-TFE3 staining is the most sensitive and specific indicator of Xp11 translocation renal cell carcinomas. Since alveolar soft part sarcoma (ASPS) is characterized by a specific chromosomal rearrangement resulting in a chimeric transcription factor (ASPSCR1-TFE3), this TFE3 IVD antibody is also a useful diagnostic tool for recognizing ASPS.
0.1 ml Concentrate - IHC672-100
1.0 ml Concentrate - IHC672-1
7.0 ml Pre-Dilute - IHC672-7
Source Mouse Monoclonal Positive Control Testes, Melanoma, Xp11.2 Translocation Renal Cell Carcinoma Dilution Range 1:50-1:200
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