CD1a is part of a heterodimer with β-2-microglobulin, and mediates the capture and presentation of antigens, primarily lipid and glycolipid antigens of self or microbial origin, to T-cells. CD1a is expressed on interdigitating and dermal dendritic cells, veiled cells, Langerhans cells, antigen-presenting cells of the lymph nodes, and cortical thymocytes. Anti-CD1a stains Langerhans cell histiocytosis and cortical T LBL/L pre-T lymphoblastic lymphoma and leukemia. In concert with S100 and CD68, CD1a is very useful for differentiating Rosai-Dorfman disease from other histiocytic diseases.

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• MSDS

CLONE:
IHC530

ISOTYPE:
IgG1

HOST SPECIES:
Mouse

CLONALITY:
Monoclonal

POSITIVE CONTROL:
Skin, Thymus

DILUTION RANGE:


INTENDED USE/REG. STATUS:
IVDR