Cluster of Differentiation 38 (CD38) is an ontogenesis marker in T-cells which is also expressed in erythrocytes, platelets, prostate epithelial cells, islet cells, smooth and striated muscle cells, renal tubules, and retinal ganglial cells. CD38(+) stained B-cells are mainly present in germinal centers of secondary lymphoid organs, while the marginal zone is usually negative. A panel of CD38, CD138, MUM1, and EMA is very useful for the diagnosis of immunodeficiency-related lymphoma, such as plasmablastic lymphoma, primary effusion lymphoma, and large B-cell lymphoma in Castleman’s disease. Recent research has found a panel of CD38, CD44, and TCL-1 to be useful in recognizing large B-cell lymphoma with c-Myc gene rearrangement, making it important in differential diagnoses of diffuse large B-cell lymphoma, Burkitt’s lymphoma, and B-cell lymphoma.

• IHC038-CD38 Datasheet-RUO

• MSDS

CLONE:
IHC038

ISOTYPE:


HOST SPECIES:
Rabbit

CLONALITY:
Monoclonal

POSITIVE CONTROL:
Plasma Cell Myeloma, Tonsil, Bone Marrow

DILUTION RANGE:


INTENDED USE/REG. STATUS:
RUO