GeneAb™ CMTM6 [IHC700] on Lung Cancer
CMTM6, belongs to the chemokine-like factor superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. CMTM6 stabilizes plasma membrane expression of PD-L1 and protects PD-L1 from lysosomal degradation by preventing STUB1-mediated PD-L1 ubiquitination. Based on the studies of CMTM6 immune system regulation, it is being investigated as an immunotherapeutic target for cancer treatment.
CLONE:
IHC700
ISOTYPE:
IgG1
HOST SPECIES:
Mouse
CLONALITY:
Monoclonal
POSITIVE CONTROL:
Tonsil
DILUTION RANGE:
INTENDED USE/REG. STATUS:
RUO