GeneAb™ CTLA-4 [IHC004] on Tonsil
GeneAb™ CTLA-4 [IHC004] on Tonsil
CTLA-4

CAT. NO. IHC004
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VOLUME
PRICE
N/A
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1
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Description

Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA-4) is a receptor on T helper cells that functions as an immune checkpoint and downregulator of immune responses. Mutations in CTLA-4 are associated with insulin-dependent diabetes mellitus, Hashimoto's thyroiditis, Graves' disease, systemic lupus erythematosus (SLE), celiac disease, primary biliary cirrhosis, thyroid-associated orbitopathy, multiple sclerosis, and other autoimmune diseases. The spliced variant of CTLA-4 in SLE is present in the patient's serum. Haploinsufficiency of CTLA-4 causes the immune system disorder known as CTLA-4 deficiency or CHAI disease (CTLA-4 haploinsufficiency with autoimmune infiltration).

Documents
DATASHEETS
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OTHERS
Specifications

CLONE:
IHC004

ISOTYPE:
IgG1

HOST SPECIES:
Mouse

CLONALITY:
Monoclonal

POSITIVE CONTROL:
Tonsil

DILUTION RANGE:


INTENDED USE/REG. STATUS:
CE-IVD


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