GeneAb™ Caldesmon [IHC522] on Appendix
GeneAb™ Caldesmon [IHC522] on Appendix
Caldesmon

CAT. NO. IHC522
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Description

Caldesmon is a marker for smooth muscle differentiation. Found in smooth muscle and other tissues, caldesmon interacts with Ca2+-calmodulin, actin, tropomyosin, myosin, and phospholipids. It inhibits the ATPase activity of myosin in smooth muscle, and mediates Ca2+-dependent inhibition of smooth muscle and non-muscle contraction. Caldesmon expression is found in Gastrointestinal Stromal Tumours (GIST), and can be used to differentiate epithelioid mesothelioma from serous papillary carcinoma of the ovary. It is also a specific marker for smooth muscle cells (SMC) and associated neoplasms; therefore, Anti-Caldesmon can be used in the study of the SMC differentiation process as well as the differentiation of other tumours with SMC-like differentiation, including leiomyosarcoma and myofibroblastic tumours.

Documents
DATASHEETS
OTHERS
Specifications

CLONE:
IHC522

ISOTYPE:
IgG2b

HOST SPECIES:
Mouse

CLONALITY:
Monoclonal

POSITIVE CONTROL:
Appendix, Breast

DILUTION RANGE:


INTENDED USE/REG. STATUS:
IVD


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