Chromogranin A is localized in secretory granules of neurons and endocrine cells in tissues, including pituitary, adrenal medulla, thyroid, pancreatic islets, and the gastrointestinal tract. Neuroendocrine cells exhibit a fine granular immunoreactivity to Anti-Chromogranin A. It is widely recognized that co-expression of keratins and chromogranin A implies a neuroendocrine lineage. High expression of chromogranin A and negative staining with Anti-Keratin is a possible indication of paraganglioma. Positive staining for chromogranin A and neuron-specific enolase is representative of neuroendocrine neoplasms. Many pituitary adenomas and prolactinomas stain positively for chromogranin A.

• Chromogranin A Datasheet

• MSDS

CLONE:
IHC544

ISOTYPE:
IgG1

HOST SPECIES:
Mouse

CLONALITY:
Monoclonal

POSITIVE CONTROL:
Pancreas

DILUTION RANGE:


INTENDED USE/REG. STATUS:
IVDR