![GeneAb™ Ep-CAM/Epithelial Specific Antigen [IHC567] on Colon](/images/product/original/EpCAM-Epithelial-Specific-Antigen-IHC567-Colon.jpg)
GeneAb™ Ep-CAM/Epithelial Specific Antigen [IHC567] on Colon
Epithelial Cell Adhesion Molecule (EpCAM) is a transmembrane glycoprotein that mediates cell-cell adhesion in epithelia. It is normally present on most baso-lateral surfaces of normal epithelial cells and is absent in myoepithelial cells, hepatocytes, adult squamous epithelia, mesothelial cells, and fibroblasts. Anti-EpCAM stains most adenocarcinomas and neuroendocrine tumours, including small cell carcinomas. A minority of renal clear cell carcinoma, renal oncocytoma, and hepatocellular carcinoma stain positively for EpCAM, while Anti-EpCAM stains nearly all basal cell carcinoma. Anti-EpCAM stains chromophobe renal cell carcinoma, papillary renal cell carcinoma, and cholangiocarcinoma more frequently. Anti-EpCAM can be useful for distinguishing malignancy in the peritoneal and pleural cavities.
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CLONE:
IHC567
ISOTYPE:
IgG1, kappa
HOST SPECIES:
Mouse
CLONALITY:
Monoclonal
POSITIVE CONTROL:
Colon Adenocarcinoma
DILUTION RANGE:
INTENDED USE/REG. STATUS:
IVDR