FOXP3 is a forkhead transcription factor family member which plays a key role in CD4+CD25+ regulatory T cell function and represents a specific marker for these cells. Specifically in IHC, FOXP3 is a marker for adult T-cell leukemia/lymphoma (ATLL). In normal lymphoid tissues, a T-cell subset in interfollicular areas shows nuclear staining. There are many characteristics of FOXP3’s role in cancer, which involves tumour progression through the suppression of T-cell activity and oncogene suppression through suppressing the expression of HER2, Skp2, SATB1 and MYC oncogenes.

• IHC773-FOXP3 Datasheet-RUO

• MSDS

CLONE:
IHC773

ISOTYPE:
IgG1

HOST SPECIES:
Mouse

CLONALITY:
Monoclonal

POSITIVE CONTROL:
Tonsil, Lymph Node

DILUTION RANGE:


INTENDED USE/REG. STATUS:
RUO