Hypoxia-Inducible Factor 1-Alpha (HIF-1-alpha or HIF1A) is an important mediator of the cellular and systemic responses to hypoxia, promoting survival and maintaining homeostasis in conditions of low oxygen. HIF1A regulates the expression of proteins such as erythropoietin, nitric oxide synthase, and mesenchymal-epidermal transition (MET) receptor, which promote angiogenesis, anaerobic metabolism, and many other survival pathways necessary in hypoxic environments. It has been suggested that tumour hypoxia and the resultant overexpression of MET by HIF1A promotes metastasis, and MET overexpression is correlated with poor prognosis and metastatic disease in the case of breast cancer. HIF-1α expression is associated with cancer progression and clinical outcome in many types of tumours, including breast cancer, type 1 endometrial carcinoma, sarcoma, head and neck tumours, and brain tumours.

• IHC601-HIF-1a Datasheet-RUO

• MSDS

CLONE:
IHC601

ISOTYPE:


HOST SPECIES:
Rabbit

CLONALITY:
Monoclonal

POSITIVE CONTROL:
Esophagus cancer

DILUTION RANGE:


INTENDED USE/REG. STATUS:
RUO