Integrase interactor 1 (INI-1), also known as hSNF5, is an integral component of the hSWI/SNF (SWItch/Sucrose Non Fermentable) chromatin remodeling complex, which facilitates DNA-dependent cellular processes including transcription, replication, and repair. The INI-1 gene is often mutated or deleted in malignant rhabdoid tumour (MRT), a tumour which is potentially mimicked by medulloblastoma and supratentorial primitive neuroectodermal tumours (sPNETs). The morphology of MRTs can often present challenges in differential diagnosis, and INI-1 has shown to be useful in distinguishing between the three conditions as the majority of medulloblastomas and sPNETs are labeled by Anti-INI-1, while a lack of nuclear labeling by the same antibody is characteristic of MRT.

• IHC608-INI-1 Datasheet-IVD

• MSDS

CLONE:
IHC608

ISOTYPE:


HOST SPECIES:
Mouse

CLONALITY:
Monoclonal

POSITIVE CONTROL:
Brain, Astrocytoma, Breast Cancer

DILUTION RANGE:


INTENDED USE/REG. STATUS:
IVD