Matrix Metalloproteinase-9 (MMP-9), also known as 92-kDa Type IV Collagenase or Gelatinase B, is a member of a family of proteins involved in degradation of the extracellular matrix (ECM). After activation in inflammatory tissues, MMP-9 is produced by neutrophils, macrophages, mast cells, and stromal cells. It has also been reported that the protein may have a crucial role in angiogenesis and neovascularization. As degradation of collagen IV in the basement membrane and ECM promotes tumour progression, including invasion, metastasis, growth, and angiogenesis, MMP-9 is involved in the development of several human malignancies. Overexpression of MMP-9 has been reported in a number of different cancers, including those of the breast and colon, as well as gastric and nasopharyngeal cancers.

• IHC109-MMP-9 Datasheet-RUO

• MSDS

CLONE:
IHC109

ISOTYPE:


HOST SPECIES:
Rabbit

CLONALITY:
Monoclonal

POSITIVE CONTROL:
Tonsil, Lymphoblastic Lymphoma, DiffuseLarge B-Cell lymphoma

DILUTION RANGE:


INTENDED USE/REG. STATUS:
RUO