Mucin 1 (MUC1) is a membrane-bound glycoprotein involved in a number of protective and cell-signaling functions, including cell-cell adhesion, proliferation, motility, invasion, and survival. Overexpression of MUC1 is clinically indicated in breast carcinomas, papillary thyroid carcinomas, and thymic carcinomas, and reports have named MUC1 as a useful marker for differentiating thymic carcinoma from type B3 thymoma. The expression of MUC1 is correlated with the grade of malignancy in thymic epithelial tumours, and loss of MUC1 expression has been associated with reactive gastropathy. MUC1 is not expressed in normal human epidermis, but it has been detected in the epidermis of psoriatic plaques of biopsies from patients diagnosed with psoriasis vulgaris.

• MUC1/EMA Datasheet IVDR

• MSDS

CLONE:
IHC623

ISOTYPE:
IgG1

HOST SPECIES:
Mouse

CLONALITY:
Monoclonal

POSITIVE CONTROL:
Breast, Colon, Associated Adenocarcinomas

DILUTION RANGE:


INTENDED USE/REG. STATUS:
IVDR