![GeneAb™ N-cadherin [IHC636] on Liver](/images/product/original/N-Cadherin-IHC636-Liver.jpg)
GeneAb™ N-cadherin [IHC636] on Liver
N-cadherin, also known as Cadherin-2 (CDH2) or Neural Cadherin (NCAD), is a transmembrane cell adhesion molecule that was originally detected in nervous tissue. It plays an important role in embryogenesis, being involved in gastrulation and neural crest development. N-cadherin is found in cancer cells and allows for transendothelial migration, which is a critical process in the metastasis of cancer. Overexpression and disorderly arrangement of N-cadherin has been noted in dilated cardiomyopathy. It has been suggested that, when considered in adjunct with the status of a number of additional cell-cell adhesion molecules, missense mutations in N-cadherin may be a potential indicator of obsessive-compulsive disorder and Tourette disorder.
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CLONE:
IHC636
ISOTYPE:
IgG2a
HOST SPECIES:
Rat
CLONALITY:
Monoclonal
POSITIVE CONTROL:
Breast
DILUTION RANGE:
INTENDED USE/REG. STATUS:
RUO