Nestin is a type IV intermediate filament protein that is expressed in dividing cells during early stages of Central Nervous System (CNS) and Peripheral Nervous System (PNS) development, as well as that of myogenic and other tissue types. Overexpression of nestin has been clinically linked to human gliomas, as well as tumours of the CNS, such as astrocytoma, ependymoma, oligodendroglioma, glioblastoma, and primitive neuroectodermal tumours. Nestin expression has also been indicated in prostatic adenocarcinoma, pancreatic ductal carcinoma, thyroid carcinoma, and mesenchymal tumours, such as gastrointestinal stromal tumour and dermatofibrosarcoma protuberans. Reports have suggested that nestin is significantly overexpressed in melanoma, and is linked to more advanced stages of the disease

• IHC105-Nestin Datasheet-RUO

• MSDS

CLONE:
IHC105

ISOTYPE:


HOST SPECIES:
Rabbit

CLONALITY:
Monoclonal

POSITIVE CONTROL:
Tonsil, Glioma

DILUTION RANGE:


INTENDED USE/REG. STATUS:
RUO