GeneAb™ PD-L1 [IHC441] on Lung
GeneAb™ PD-L1 [IHC441] on Lung
PD-L1

CAT. NO. IHC441
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Description

Programmed Death-Ligand 1 (PD-L1), CD274, or B7 Homolog 1 (B7-H1), is a transmembrane protein involved in suppressing the immune system and rendering tumour cells resistant to lysis through binding of the Programmed Death-1 (PD-1) receptor. Overexpression of PD-L1 may allow cancer cells to evade the actions of the host immune system. In renal cell carcinoma, upregulation of PD-L1 has been linked to increased tumour aggressiveness and risk of death. When considered in adjunct with CD8+ tumour-infiltrating lymphocyte density, expression levels of PD-L1 may be a useful predictor of multiple cancer types, including stage III non-small-cell lung cancer, hormone receptor negative breast cancer, and sentinel lymph node melanoma.

Documents
DATASHEETS
OTHERS
Specifications

CLONE:
IHC441

ISOTYPE:
IgG1, kappa

HOST SPECIES:
Mouse

CLONALITY:
Monoclonal

POSITIVE CONTROL:
Tonsil, Lung Adenocarcinoma

DILUTION RANGE:


INTENDED USE/REG. STATUS:
IVD


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