Postmeiotic Segregation Increased 2 (PMS2) is a DNA repair protein involved in mismatch repair. Mutations and deficiencies in the PMS2 gene have been linked to microsatellite instability and malignancies such as hereditary nonpolyposis colorectal cancer and endometrial cancer. Expression levels of the PMS2 protein may be useful as a screening tool for Lynch syndrome after a colorectal cancer diagnosis. Anti-PMS2 is recommended to be used as part of a panel along with antibodies against MSH2, MSH6, and MLH1.
CLONE:
IHC422
ISOTYPE:
IgG, kappa (Rab)
HOST SPECIES:
Rabbit
CLONALITY:
Monoclonal
POSITIVE CONTROL:
Colon Cancer
DILUTION RANGE:
INTENDED USE/REG. STATUS:
RUO
ADDITIONAL INFORMATION:
NordiQC Rating: Good (Assessment Run 62 2021)
