ROS1 serves as a receptor tyrosine kinase. Gene rearrangement events involving ROS1 have been described in lung and other cancers, and such tumours have been found to be remarkably responsive to small molecule tyrosine kinase inhibitors. Multiple studies have observed ROS1 gene rearragement events in approximately 1% of lung cancers and showed that inhibition of tumour cells bearing ROS1 gene fusions by crizotinib or other ROS1 tyrosine kinase inhibitors was effective in vitro.

• IHC094-ROS1 Datasheet-RUO

• MSDS

CLONE:
IHC094

ISOTYPE:
IgG2a

HOST SPECIES:
Rabbit

CLONALITY:
Monoclonal

POSITIVE CONTROL:
ROS1 Fusion NSCLC

DILUTION RANGE:


INTENDED USE/REG. STATUS:
RUO