![GeneAb™ SALL4 [IHC659] on Seminoma](/images/product/original/SALL4-IHC659-Seminoma.jpg)
GeneAb™ SALL4 [IHC659] on Seminoma
Sal-Like Protein 4 (SALL4) is a zinc finger transcription factor found in germ cells and human blood progenitor cells, with functional involvement in modulating Oct-4 to maintain embryonic stem cell pluripotency. SALL4 is a useful marker for acute myeloid leukemia, B-cell acute lymphocytic leukemia, intratubular germ cell neoplasia, seminomas/dysgerminomas, and yolk sac tumours (both pediatric and postpubertal). Anti-SALL4 is used to detect embryonal carcinomas, hepatocellular carcinoma (HCC), gliomas, ovarian primitive germ-cell tumours, choriocarcinomas, spermatogonia, teratoma, gastric cancer, breast cancer, and lung cancer. Expression of SALL4 is often associated with poor prognosis in HCC, and with metastasis in endometrial cancer, colorectal carcinoma, and esophageal squamous cell carcinoma.
CLONE:
IHC659
ISOTYPE:
IgG1
HOST SPECIES:
Mouse
CLONALITY:
Monoclonal
POSITIVE CONTROL:
Seminoma, Dysgerminoma
DILUTION RANGE:
INTENDED USE/REG. STATUS:
IVD