SRY (Sex Determining Region Y)-Box 10 (SOX-10), also known as Transcription Factor SOX-10, is a nuclear transcription factor that acts in regulation of embryonic development and in the specification and differentiation of cells of melanocytic lineage. SOX-10 is diffusely expressed in neurofibromas and schwannomas, and mutations in the SOX-10 gene are linked to Waardenburg-Shah and Waardenburg-Hirschsprung's disease. Anti-SOX-10 has been shown to be sensitive for conventional, spindled, and desmoplastic melanoma, and has been used to detect metastatic melanoma and nodal capsular nevus in sentinel lymph nodes.

• SOX-10 IVDR Datasheet

• MSDS

CLONE:
IHC010

ISOTYPE:
IgG1

HOST SPECIES:
Mouse

CLONALITY:
Monoclonal

POSITIVE CONTROL:
Melanoma, Skin Melanocytes

DILUTION RANGE:


INTENDED USE/REG. STATUS:
IVDR