A-1-Antitrypsin (In the pipeline)
Alpha-1-Antitrypsin (A1AT or AAT) is a protease inhibitor synthesized by the liver which plays a role in acute inflammation. The application of A1AT staining is to identify A1AT deficiency, as well as benign and malignant yolk sac carcinomas, and hepatic cancers. Some reports have found α-A1AT staining to be useful for recognizing benign and malignant histiocytic tumours, and screening patients with cryptogenic cirrhosis, liver disease, and portal fibrosis of unknown etiology.
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- Clausen PP. Acta Pathol Microbiol Scand A. 1980; 88:299-306.