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GeneAb™ AEG1 Antibody
GeneAb
TM
AEG1 [IHC507] on Stomach Cancer
Reference Panels
Breast/Gynecological Pathology
Dermatopathology
Gastrointestinal (GI) Pathology
Genitourinary (GU) Pathology
Head and Neck Pathology
Hematopathology
Neuropathology
Pediatric Pathology
Pulmonary Pathology
Soft Tissue Pathology
Cytopathology
GeneAb™
AEG1
(Coming soon)
Select Format:
Concentrate
Predilute
Positive Control Slides
Select Volume:
0.1 ml
1 ml
7 ml
25 ml
3 slides/package
Price:
$0.00
Quantity:
Cat. No.
IHC507-100
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Description
Astrocyte Elevated Gene-1 protein (AEG1) is an oncoprotein involved in many hallmarks of aggressive cancer progression such as apoptosis evasion, cell movement, transformation, invasion, angiogenesis, metastasis and drug resistance. AEG1 plays an important role in anchorage-independent growth of cancer cells, which allow for tumor cell expansions. It is also implicated in diverse physiological and pathological processes, such as development, inflammation, neurodegeneration, migraine and Huntington's disease. AEG1 is found to be overexpressed in melanoma, malignant glioma, and breast cancer, and is associated with poor clinical outcomes in hepatocellular carcinoma. The protein is a potential therapeutic target for reducing metastasis and enhancing chemotherapy.
References
Brown DM, et al. Cancer Cell. 2004; 5:365–74.
Yoo BK, et al. Pharmacol Ther. 2011; 130:1–8.
Yoo BK, et al. J Clin Invest. 2009; 119:465–77.
Hu G, et al. Cancer Cell. 2009; 15:9–20.
Specifications
Clone
IHC507
Source
Mouse Monoclonal
Positive Control
Glioblastoma
Dilution Range
1:50-1:200
Literature
Data Sheet
SDS Sheet
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