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Anaplastic Lymphoma Kinase (ALK) is a receptor tyrosine kinase which plays a role in brain and nervous system development. ALK is typically expressed at low levels in regions of the developing central and peripheral nervous system, such as the neonatal brain and spinal cord. Most common genetic alterations for this gene are chromosomal translocations, which result in multiple ALK fusion proteins that are involved in tumourigenesis, as in the case of anaplastic large cell lymphoma (ALCL), lung adenocarcinoma and inflammatory myofibroblastic tumors. Aberrant ALK expression is also found in other tumours such as familial neuroblastoma, non-small cell lung carcinoma (NSCLC), and brain cancers.
  • References
    1. Iwahara T, et al. Oncogene. 1997; 14: 439–49.
    2. Falini B, et al. Am J Pathol. 1998; 153:875-86.
    3. Mino-Kenudson M, et al. Clin Cancer Res. 2010; 16:1561-71.
    4. Paik JH, et al. J Thorac Oncol. 2011; 6:466-72.
    5. Mossé YP, et al. Nature. 2008; 455:930–5.
    6. Kim H, et al. J Thorac Oncol. 2011; 6:1359-66.


Clone IHC509
Source Mouse Monoclonal
Positive Control Anaplastic Large Cell Lymphoma
Dilution Range 1:50-1:200