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Description

Arginase-1, encoded by the ARG1 gene, is a cytosolic metalloenzyme expressed predominantly in hepatocytes which plays a key role in the urea cycle by catalyzing the hydrolysis of arginine to ornithine and urea. Argininemia is an inherited autosomal recessive disorder characterized by a buildup of arginine and ammonia in the blood. Anti-Arginase-1 is highly specific for hepatocytes, and is therefore a sensitive and specific marker of benign and malignant hepatic tumors.

References

1. Morris SM Jr. Br J Pharmacol. 2009; 157:922–930.
2. Uchino T, et al. Human Genetics. 2009; 96:255–60.
3. Yan BC, et al. Am J Surg Pathol. 2010; 34:1147-1154.