GeneAb™

BG8, Lewisy

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Cat. No.

IHC517-100

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Description

BG8 LewisY, also known as LewisY blood antigen or simply BG8, is a blood group antigen that has been identified in many studies as a potential marker for differentiation between pulmonary adenocarcinoma (PACA) and epithelioid mesothelioma (EM). It has been reported that sensitivity of non-mesothelial antigens for adenocarcinoma is organ-dependent. When attempting to differentiate epithelioid mesothelioma from adenocarcinoma, BG8 LewisY performed at a sensitivity of 98% in the breast cancer group, and 100% in the lung cancer group.

Specifications

Clone IHC517
Source Mouse Monoclonal
Positive Control Lung Adenocarcinoma
Dilution Range 1:100 - 1:200

References

  1. Sheibani K, et al. Am J Surg Pathol. 1991; 15:779-84.
  2. Marchevsky AM, et al. Appl Immunohistochem Mol Morphol. 2007; 15:140-4.
  3. Davidson B, et al. Virchows Arch. 1999; 435:43-9.
  4. Ordonez NG. Am J Surg Pathol. 2003; 27:1031-51.
  5. Ordonez NG. Am J Surg Pathol. 2000; 24: 598-606.
  6. Ordonez NG. Am J Clin Pathol. 1998; 109:85-9.
  7. King JE, et al. Histopathology. 2006; 48:223-32.
  8. Kao SC, et al. Pathology. 2011; 43:313-7.
  9. Yaziji H, et al. Mod Pathol. 2006; 19:514-23.